Rutin promotes osteogenic differentiation of mesenchymal stem cells (MSCs) by increasing ECM deposition and inhibiting p53 expression

Dongyang Li; Wanru Yin; Chao Xu; Yongmin Feng; Xin Huang; Junfeng Hao; Chao Zhu

doi:doi:10.18632/aging.205546

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Research Paper Volume 16, Issue 4 pp 3583—3595

Rutin promotes osteogenic differentiation of mesenchymal stem cells (MSCs) by increasing ECM deposition and inhibiting p53 expression

Figure 4. Kyoto Encyclopedia of Genes and Genomes (KEGG) functional enrichment of DEGs in osteogenic differentiation of MSCs. (A) The main enrichment results of the up-regulated genes (Count represents the number of enriched genes). (B) Heatmap of the relationship between up-regulated genes and KEGG terms. (C) The main enrichment results of the downregulated genes. (D) Heatmap of the relationship between downregulated genes and KEGG terms.