Research Paper Volume 16, Issue 4 pp 3554—3582

Figure 5. Characteristics of cuproptosis metabolism in molecular subtypes and tumour somatic mutation. (A) Differences in CupScore between different age status. (P = 0.012, Kruskal-Wallis test). (B) Differences in CupScore between different IHD1 status. (P < 0.001, Kruskal-Wallis test). (C) Differences in CupScore between different GBM molecular subtypes. (P < 0.001, Kruskal-Wallis test). (D) Survival analyses for high (n = 160) and low (n = 223) CupScore GBM groups in merge cohort (TCGA and CGGA, P = 0.032, Log-rank test). (E) Survival analyses for subgroup patients stratified by both CupScore and treatment with pharmacological chemotherapy (TMZ, temozolomide) using Kaplan–Meier curves. (P < 0.001, Kruskal-Wallis test). (F, G) The waterfall plot of tumour somatic mutation established by those with high- (F) and low CupScore (G).