Research Paper Volume 16, Issue 4 pp 3531—3553

Figure 5. Enrichment analysis in the TCGA all cohort. (A, B) Bar plot and bubble plot of the Gene ontology (GO) enrichment. The results were divided into the biological process (BP), cell component (CC), and biological function (MF). The top five significant GO enrichment results are shown. (C, D) Bar plot and bubble plot of Kyoto Encyclopedia of Genes and Genomes enrichment. (KEGG) (E) Gene Set Enrichment Analysis (GSEA) revealed that the cell cycle was active in the high-risk group. (F) A protein-protein interaction network was generated to reveal interactions among the top ten genes involved in the “cell cycle”. (G) CHEK1 expression analysis between high and low-risk groups (P<0.05). (H) Gene Set Enrichment Analysis (GSEA) revealed that the “T cell receptor signaling pathway” was active in a low-risk group. (I) Representative genes involved in the “T cell receptor signaling pathway” were used to construct a protein-protein interaction network. (J) The expression profile of a critical checkpoint gene IKBKG was investigated in normal and tumor groups (P<0.05). (K) Survival analysis was performed on patients aged >=65.