Research Paper Volume 16, Issue 4 pp 3404—3419

Figure 7. OXA inhibits neuronal degeneration in the contused peripheral cortex after TBI and improves neural function after TBI. (A) Typical images of Fluoro Jade B (FJB) staining of injured peripheral cortex 24 hours after injury. (B) Quantitative analysis showed number of FJB positive cells in TBI group remained greater in contrast with sham operation group. OXA effectively reduces number of degenerated neurons in contusion surrounding cortex following TBI. Data are shown as mean ± standard deviation. (C) Neurological functions were analysed via mNSS before treatment with OXA. There was no significant difference in mNSS scores between the TBI, TBI+OXA and TBI+NS group. Data are shown as median (P25, P75). (D) Neurological functions were analysed via mNSS 24 hours following TBI. Score in either TBI or TBI+NS group was tremendously greater relative to sham operation group, and OXA treatment reduced neurological deficit score. Data are shown as median (P25, P75), ^*p < 0.05, ^**p < 0.01, ^***p < 0.001, ^nsp > 0.05.