Research Paper Volume 16, Issue 4 pp 3404—3419

Figure 3. OXA alleviates TBI induced Ferroptosis and oxidative stress. (A) Perls staining showed iron deposition around the injured brain tissues of each rat group 24 hours after TBI. (B) Cortical non-heme iron was measured in sham, TBI, TBI+OXA, and TBI+NS groups. (C) Representative immunohistochemical staining of GPX4 and PTGS2. (D–G) Biochemical analysis was used to assess contents of GSH, SOD, MDA, and ROS in injured peripheral cortex of each group 24 hours following TBI. Findings are shown as mean ± standard deviation. ^*P < 0.05, ^**P < 0.01, ^***P < 0.001, ^nsp > 0.05.