Research Paper Volume 16, Issue 4 pp 3386—3403
Investigation on the mechanism of the combination of eremias multiocellata and cisplatin in reducing chemoresistance of gastric cancer based on in vitro and in vivo experiments
Figure 7. Effect of EM combined with DDP on the NF-κB/Snail pathway and expression of drug resistance-related proteins. (A, B): Western plots of P65, p-p65, Snail, E-cad, P-gp, MRP1, LRP proteins. (a) Expression of p65 protein. (b) Expression of p-p65 protein. (c) Expression of Snail protein. (d) Expression of E-cad protein. (e) Expression of P-gp protein. (f) Expression of MRP1 protein. (g) Expression of LRP protein. (C): Western plots of PI3K, AKT, mTOR, P-PI3K, P-AKT, and P-mTOR proteins. (h) Expression of PI3K protein. (i) Expression of P-PI3K protein. (j) Expression of AKT protein. (k) Expression of P-AKT protein. (l) Expression of mTOR protein. (m) Expression of P-mTOR protein. All experiments were repeated three times. nsp > 0.05, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.