Research Paper Volume 16, Issue 4 pp 3363—3385

Figure 4. NUDT21 is involved in cancer DNA repair, tumor stemness and epigenetic regulation. (A) Heat map showing the association between NUDT21 and 5 MMR genes in pan-cancer. *, ** and *** represent p <0.05, p <0.01 and p <0.001, respectively. (B) Interrelationship between tumor stemness and NUDT21 expression in the lollipop plot, the size of the dots represents the sample size, while the color indicates the p-value. (C) Correlation scatter plots of 12 cancers showing the correlation between HRR features of 30 genes and NUDT21 expression. (D) Circos plot showing the correlation between four methyltransferases and NUDT21 expression. The first (outermost) circle refers to the name of the pan-cancer, and the second layer indicates the four sulfotransferases DNMT1, DNMT2, DNMT3A, and DNMT3B labeled in red, blue, green, and purple, respectively. The third layer shows green and brown representing negative and positive correlation coefficient values, respectively, and the innermost blue block indicates p-values (lower p-values correspond to dark blue). (E) The correlation between NUDT21 methylation levels and CTL correlates was retrieved in the methylation module of the TIDE web tool, the third column is the CTL correlation, and the fourth column is the CTL dysfunction z-score of the interaction term. (F) Association between NUDT21 methylation levels and CTL markers and between survival analysis of NUDT21 hypermethylated and hypomethylated subgroups in scatter plots and Kaplan-Meier plots. (G) Heat map showing the correlation between NUDT21 expression and RNA modifications in pan-cancer. * p< 0.05.