Review Volume 16, Issue 4 pp 4052—4073

Figure 1. LncRNAs categories are decided by the location of lncRNAs and surrounding protein-coding genes. (A) Intergenic lncRNAs are autonomously transcribed non-coding RNAs longer than 200 nucleotides that do not overlap annotated coding genes. (B) Intronic lncRNAs are lncRNAs that locate inside of an intron of a protein-coding gene and can initiate in either direction. (C) Bidirectional lncRNAs are transcripts that are transcribed from the same promoter as a protein-coding gene but in the opposite direction. (D) Sense lncRNAs overlap with one or more introns and/or exons of a protein-coding gene in the sense direction. (E) Antisense lncRNAs are transcribed from the opposite strand of protein-coding genes.