Research Paper Volume 16, Issue 1 pp 779—798
SPC25 as a novel therapeutic and prognostic biomarker and its association with glycolysis, ferroptosis and ceRNA in lung adenocarcinoma
Figure 8. Prediction and construction of the ceRNA network related to SPC25 in LUAD. (A) The results of the analysis of microT-CDS and mirDIP databases are presented in a Venn diagram. (B) Differential expression analysis of 8 miRNAs in the TCGA LUAD dataset. (C) The expression of hsa-miR-451a in tumor samples from the TCGA LUAD dataset was significantly lower than in normal samples. (D) Potential binding sites between SPC25 and hsa-miR-451a were predicted using the RNAHybrid online tool. (E) The results of the analysis of miRNet and ENCORI databases are presented in a Venn diagram. (F) Differential expression analysis of 3 lncRNAs in the TCGA LUAD dataset. (G) The expression of SNHG15 in tumor samples from the TCGA LUAD dataset was significantly higher than in normal samples. (H) Potential binding sites between hsa-miR-451a and SNHG15 were predicted using the RNAHybrid online tool. (***p < 0.001; **p < 0.01; *p < 0.05; Abbreviation: ns: not significant).