Research Paper Volume 16, Issue 1 pp 779—798
SPC25 as a novel therapeutic and prognostic biomarker and its association with glycolysis, ferroptosis and ceRNA in lung adenocarcinoma
Figure 6. Association between SPC25 and glycolytic-related genes. (A) The correlation between SPC25 expression and 11 glycolysis-related genes was analyzed in the TCGA LUAD dataset and GSE31210 dataset. (B, C) The differential expression of 11 glycolysis-related genes between the high and low SPC25 expression groups was analyzed in the TCGA LUAD dataset and GSE31210 dataset. (D) Prognostic analysis of 11 glycolysis-related genes was conducted in the TCGA LUAD dataset. (E) The UpSet plot displays the intersection of genes with statistically significant differences in the aforementioned analyses. (F) Differences in the expression of 4 glycolysis-related genes between the experimental group and the control group in siRNA transfection experiments. (***p < 0.001; **p < 0.01; *p < 0.05; Abbreviation: ns: not significant).