Research Paper Volume 16, Issue 1 pp 779—798
SPC25 as a novel therapeutic and prognostic biomarker and its association with glycolysis, ferroptosis and ceRNA in lung adenocarcinoma
Figure 5. GSEA analysis and glycolytic capacity analysis. (A) REACTOME_GLYCOLYSIS. (B) WP_GLYCOLYSIS_AND_GLUCONEOGENESIS. (C) WP_AEROBIC_GLYCOLYSIS. (D) WP_GLYCOLYSIS_IN_SENESCENCE. (E) HALLMARK_GLYCOLYSIS. (F) Interference with SPC25 expression can significantly reduce the lactate production in LUAD cells. (G, H) Inhibition of SPC25 expression can significantly reduce the uptake of 2-NBDG by LUAD cells. MFI, mean fluorescence intensity. (***p < 0.001; **p < 0.01; *p < 0.05; Abbreviation: ns: not significant).