Research Paper Volume 16, Issue 1 pp 685—700
ZIP4 upregulation aggravates nucleus pulposus cell degradation by promoting inflammation and oxidative stress by mediating the HDAC4-FoxO3a axis
Figure 6. The influence of ZIP4 on the HDAC4-FoxO3a pathway. (A, B) Western blotting was implemented to determine the HDAC4, FoxO3a, Sirt1 and NF-κB profiles in NP cells after IL-1β treatment. N=3. **P<0.01, ***P<0.001 (vs. CON); ++P<0.01, +++P<0.001 (vs. vector+IL-1β or sh-NC+IL-1β).