Research Paper Volume 16, Issue 1 pp 627—647
Targeting of FSP1 regulates iron homeostasis in drug-tolerant persister head and neck cancer cells via lipid-metabolism-driven ferroptosis
Figure 4. Inhibition FSP1 significantly suppressed metastasis in the patient-derived xenograft mouse model. (A) Flowchart showing the in vivo experimental design and treatment schedule. (B) Tumor size and body weight curve over time indicated that the combination of cisplatin and FSP1 inhibitor suppressed tumor growth and caused no apparent systematic toxicity. (C) The Kaplan–Meier survival curve indicated that the group of mice receiving combined treatment had a higher survival ratio than did the other groups. (D) The Q-score of tissue staining. (E) Immunostaining analysis of tumor sections indicated that the combined treatment prominently suppressed FSP1, ACSL4, SOD2, and ki67 expression compared with other sections. (**p < 0.01; ***p < 0.001).