Research Paper Volume 16, Issue 1 pp 617—626
GDF15 restrains myocardial ischemia-reperfusion injury through inhibiting GPX4 mediated ferroptosis
Figure 2. The ferroptosis induced by MIRI was remarkably alleviated by pc-DNA-GDF15. (A) Detection of mitochondrial damage with TEM (bar: 100 nm); (B) Relative protein expression levels of GPX4, FACL4, and XCT4 in heart tissues. (C) IHC staining of GPX4 in the heart tissues (bar: 200 μm, magnification: 100×). *P < 0.05, **P < 0.01, ***P < 0.001.