Research Paper Volume 16, Issue 1 pp 617—626
GDF15 restrains myocardial ischemia-reperfusion injury through inhibiting GPX4 mediated ferroptosis
Figure 1. Overexpression of GDF15 greatly inhibited MIRI and improved cardiac function. (A) HE staining of cardiac tissues in different groups (bar: 200 μm, magnification: 100×); (B, C) Masson staining of cardiac tissues in different groups and infarction ration analysis (bar: 200 μm, magnification: 100×); (D) Sirius red staining of cardiac tissues in different groups (bar: 200 μm, magnification: 100×). (E–G) Echocardiographic measurement, and analysis of LVFS and LVEF. *P < 0.05, **P < 0.01, ***P < 0.001.