Research Paper Volume 16, Issue 1 pp 445—465
Tumor-associated macrophages and PD-L1 in prostate cancer: a possible key to unlocking immunotherapy efficacy
Figure 6. M2-TAMs are major immune-modulator in PCa. (A, B) The landscape of 22 immune cells in PCa. The infiltration factions of the 22 analyzed cell types were calculated by CIBERSORTx program in TCGA-PRAD (A) and prad_su2c_2019 datasets (B). (C, D) UMAP showed the distribution of cell clusters in the GSE172301 dataset, and the expression levels of CD274 mRNA were shown as blue dots in log2TMP+1. (E) Heatmap showed the expression levels of CD274 mRNA across multiple cell types in TME. (F, G) Heatmap showed the correlation among the 22 immune cells in TCGA-PRAD (F) and prad_su2c_2019 dataset (G).