Research Paper Volume 16, Issue 1 pp 367—388
Multidimensional comprehensive and integrated analysis of the potential function of TMEM25 in renal clear cell carcinoma with low expression status
Figure 5. Immune infiltration correlation analysis of TMEM25 in ccRCC. (A) The ssGSEA algorithm analyzes the correlation between TMEM25 and various immune cell infiltrations in ccRCC. (B–G) The TIMER database used the cibersort-abs algorithm to calculate the correlation between TMEM25 expression and mast cell activated, NK cell resting, and Tregs in ccRCC, and plotted the Kaplan-Meier curves in relation to their prognosis. (H–J) A more comprehensive analysis conducted by TISIDB showed that TMEM25 expression in ccRCC is strongly associated with a variety of immune checkpoints, immunosuppressants, and MHC molecules. (K, L) The TISIDB website analyzed the correlation between TMEM25 expression in ccRCC and immune subtypes, and examined the relationship between its copy number and immune infiltrating cells. (*p < 0.05, **p < 0.01, ***p < 0.001).