Research Paper Volume 16, Issue 1 pp 367—388

Figure 3. Construction and validation of nomograms containing TMEM25 expression data. (A) Nomograms containing age, pathologic grade, histologic grade and TMEM25 expression were constructed. The TCGA-KIRC cohort was randomized into TRAINING and TEST groups to mutually validate the ability of the model in combination with the survival prognosis of the patients. (B) In the training group, the ROC curves demonstrated AUC values of 0.864, 0.84, and 0.808 for predicting survival at 1, 3, and 5 years, respectively; the calibration plots (C) and clinical decision curves (D) at 1, 3, and 5 years were consistent in indicating that the model had strong predictive power. (E) Similarly, in the test group, the ROC curves demonstrated AUC values of 0.823, 0.749, and 0.71 for predicting survival at 1, 3, and 5 years, respectively; the results of the calibration plots (F) and clinical decision curves (G) at 1, 3, and 5 years were consistent with the training group.