Research Paper Volume 16, Issue 1 pp 348—366
SNRPB promotes the progression of hepatocellular carcinoma via regulating cell cycle, oxidative stress, and ferroptosis
Figure 6. SNRPB knockdown affects the expression of downstream genes associated with cell cycle, oxidative stress and ferroptosis. (A) GO-KEGG of DEGs. (B) GSEA of the TCGA dataset: the high SNRPB expression associated DGEs are enriched in cell cycle related genes and that low SNRPB expression associated DGEs are enriched in oxidative stress and ferroptosis related genes. (C) Correlation between SNRPB expression and CDK1, CyclinB1 (CCNB1), CDK4, KEAP1, PTPN2 (TCPTP), SLC7A11, GPX4 and ACSL4 expression. (D) The protein expression levels of CDK1, CyclinB1 (CCNB1), CDK4, and SLC7A11 after SNRPB knockdown were evaluated by Western blotting.