Identification of aging-related genes in diagnosing osteoarthritis via integrating bioinformatics analysis and machine learning

Jian Huang; Jiangfei Zhou; Xiang Xue; Tianming Dai; Weicong Zhu; Songsong Jiao; Hang Wu; Qingqi Meng

doi:doi:10.18632/aging.205357

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Research Paper Volume 16, Issue 1 pp 153—168

Identification of aging-related genes in diagnosing osteoarthritis via integrating bioinformatics analysis and machine learning

Figure 7. The expression levels of four hub genes were shown by boxplots. (A) Expression of the hub genes in the GSE114007 dataset, HMGB2, CDKN1A, JUN, andDDIT3 expression were all down-regulated in OA samples. (B) The expression of the Hub gene in an external GSE169077 data set (^**p < 0.01; ^***p < 0.001).