Research Paper Volume 15, Issue 23 pp 14372—14383
Melatonin exhibits partial protective effects against gemcitabine- and cisplatin-induced kidney and reproductive injuries in mice
Figure 3. Effects of melatonin and gemcitabine plus cisplatin on the kidney. The histogram illustrates the percentage of (A) kidney weight/body weight under different treatments and (B) detection of creatinine in the serum. A tangential section of the mouse kidney stained with H&E and trichrome is shown in (C). GC refers to gemcitabine plus cisplatin, ML represents low dose (10 mg/kg) melatonin, and MH represents high dose (30 mg/kg) melatonin. The data are presented as mean ± SEM, with 6 mice per group (N = 6 mice per group). * p < 0.05, ** p < 0.01 compared to the control or GC group.