Research Paper Volume 15, Issue 23 pp 14333—14371
Single-cell dissection reveals the role of aggrephagy patterns in tumor microenvironment components aiding predicting prognosis and immunotherapy on lung adenocarcinoma
Figure 9. Identification of candidate agents with higher drug sensitivity in high ADPS group. (A) The correlation of gene expression and immune score. (B) The correlation of gene expression and immune cell types. (C) A Venn diagram for summarizing included compounds from CTRP and PRISM datasets. (D) Barplot of gemcitabine, paclitaxel, and BI-2536 CMap scores in patients with high ADPS. (E) Schematic outlining the strategy to identify agents with higher drug sensitivity in high ADPS patients. (F, G) The result of Spearman’s correlation analysis and differential drug response analysis of CTRP-derived compounds (F) and profiling relative inhibition simultaneously in mixtures (PRISM)-derived compounds (G). (H, I) The results of differential drug response analysis of CTRP -derived compounds (H) and PRISM -derived compounds (I), The lower the value of the y-axis, the greater the drug sensitivity. *p < 0.05; **p < 0.01; ***p < 0.001. Abbreviation: ns: not significant.