Research Paper Volume 15, Issue 23 pp 14333—14371
Single-cell dissection reveals the role of aggrephagy patterns in tumor microenvironment components aiding predicting prognosis and immunotherapy on lung adenocarcinoma
Figure 5. Multiple aggrephagy cell subtypes influenced the prognosis and immunotherapy response of LUAD patients. (A) The landscape of all cell-cell communication within all identified aggrephagy subtypes. (B) A hazard ration of different aggrephagy subtypes in 8 LUAD cohorts. (C) Odd ratio produced by logistic regression of different subtypes in 8 cohorts. (D–L) All aggrephagy cell subtypes could distinguish the survival of patients in Meta cohort. (M) Various aggrephagy-related subtypes demonstrated significantly different infiltration in responders and non-responders of ICB in TCGA cohorts, as predicted by TIDE. Mann Whitney-Wilcoxon test was applied between responders and non-responders. *p < 0.05; **p < 0.01; ***p < 0.001. Abbreviation: ns: not significant.