Research Paper Volume 15, Issue 23 pp 14333—14371
Single-cell dissection reveals the role of aggrephagy patterns in tumor microenvironment components aiding predicting prognosis and immunotherapy on lung adenocarcinoma
Figure 1. Overview of aggrephagy gene expression in the scRNA-seq for LUAD. (A) The overall design of this study. (B) The GSVA scores based on the aggrephagy gene set were compared between normal and LUAD samples. (C) t-SNE plot colored by 18 cluster of cells. (D) Cell type annotations clustered by Seurat t-SNE in the scRNA-seq data. (E) Dot plot showing representative marker genes for each cell type. (F) Bubble plot showing aggrephagy scores for each cell type. (G) Dot plot showing the expression level of aggrephagy genes in all cell types. (H, I) Expression of example genes VIM (H), and TUBA1C (I) in different cell types. (J) The difference in average aggrephagy score in each cell type in normal and LUAD samples. *p < 0.05; **p < 0.01; ***p < 0.001. Abbreviation: ns: not significant.