Research Paper Volume 15, Issue 23 pp 13593—13607

Figure 3. (A) Infection with SARS-CoV-2 variants alters the gene expression patterns of SAEC cells. Co-expression Venn Diagram showing regulated genes of mock, omicron- and delta variant infected cells identified via mRNA-sequencing 8 h p.i.. (B) Pathways with significant enrichment scores (-log (p-value)) revealed by QIAGEN Ingenuity Pathway Analysis 8 h p.i. indicates significant increase of gene regulation in omicron-infected cells. (C, D) Representative heatmaps of genes regulated due to omicron variant or delta variant, after 8 h (C) or 24 h (D) p.i. shown in relation to pathway or gene families. Here, selective genes for cyclins, senescence-associated secretory phenotype (SASP), Damage-associated molecular patterns (DAMPS), integrins, interleukins, and cell cycle are shown.