HACE1 expression in heart failure patients might promote mitochondrial oxidative stress and ferroptosis by targeting NRF2

Peiyi Yin; Yongbin Wu; Xiang Long; Shuqiang Zhu; Shiwei Chen; Feng Lu; Kun Lin; Jianjun Xu

doi:doi:10.18632/aging.205272

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Research Paper Volume 15, Issue 23 pp 13888—13900

HACE1 expression in heart failure patients might promote mitochondrial oxidative stress and ferroptosis by targeting NRF2

Figure 8. The inhibition of NRF2 reduced the effects of HACE1 in model of heart failure. NRF2 and GPX4 protein expression (A, B), MDA/ROS/SOD/GSH/GSH-PX levels (C–G), cell viability (H), LDH activity (I), IL-1α level (J), Iron concentration levels (K), JC-1 disaggregation (L). NRF2 and GPX4 protein expression in blot and immunofluorescence (M, N). ##p<0.01 compared with control group, **p<0.01 compared with HACE1 group.