HACE1 expression in heart failure patients might promote mitochondrial oxidative stress and ferroptosis by targeting NRF2

Peiyi Yin; Yongbin Wu; Xiang Long; Shuqiang Zhu; Shiwei Chen; Feng Lu; Kun Lin; Jianjun Xu

doi:doi:10.18632/aging.205272

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Research Paper Volume 15, Issue 23 pp 13888—13900

HACE1 expression in heart failure patients might promote mitochondrial oxidative stress and ferroptosis by targeting NRF2

Figure 7. HACE1 promoted NRF2 activity levels by its Ubiquitination in model of heart failure. NRF2 protein expression (A–C), HACE1 and NRF2 expression (Microscopic display, (D), ACE1 protein connected with NRF2 protein (IP, E), NRF2 Ubiquitination (F). ##p<0.01 compared with control group or si-nc group.