Research Paper Volume 15, Issue 23 pp 13888—13900

HACE1 expression in heart failure patients might promote mitochondrial oxidative stress and ferroptosis by targeting NRF2

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Figure 2. HACE1 reduced oxidative stress in vitro model. HACE1 mRNA expression (A), MDA, ROS, SOD, GSH and GSH-px levels (BF), collagen I, collagen III and TGF-β mRNA expression (GI). ##p<0.01 compared with control group. Immunofluorescence images of HACE1 (J).