Research Paper Volume 15, Issue 23 pp 13854—13864
Long noncoding RNA MEG8 induces an imbalance of Th17/Treg cells through the miR-107/STAT3 axis in Henoch-Schonlein purpura rats
Figure 2. The overexpression level of MEG8 promotes the differentiation of Treg cells in CD4+ T cells of HSP rats. (A) RT-qPCR analysis of MEG8 in peripheral blood CD4+ T cellular populations derived from control groups transfected with the empty vector (Vector group) or MEG8 over-expression vector (MEG8 cohort). (B) MEG8 was analyzed through RT-qPCR. (C–F) Th17/Treg cellular population analysis. (G) The analysis of peripheral blood CD4 + T cells, HSP + carrier group or HSP + MEG8 group in the control and HSP rats through qRT-PCR. *P <0.01 vs. Vector group; #P <0.01 vs. Control group; ※P <0.01 vs. HSP+ vector group.