Research Paper Volume 15, Issue 22 pp 12702—12722
Chronological aging impacts abundance, function and microRNA content of extracellular vesicles produced by human epidermal keratinocytes
Figure 8. Aged EVs impact the early phases of wound healing in mice. Wound closure assay on mice treated with EVs from old keratinocytes. (A) Representative photographs of full-thickness excisional wounds treated at day 0 (D0) with NaCl (Control n = 4) or with EVs from old human keratinocytes (n = 8) every day from day 0 to day 10 (D10). (B) Quantitative analysis of wound healing closure in each group, expressed as a percentage of the initial wound area (*p-value < 0.05. **p-value < 0.01. Student’s t-test).