Research Paper Volume 15, Issue 22 pp 13213—13238
A prognostic risk model for programmed cell death and revealing TRIB3 as a promising apoptosis suppressor in renal cell carcinoma
Figure 4. Analysis of clinical relevance and clinical model construction based on PRPCDGs risk signature. (A) Heatmap of PRPCDGs’ expression in TCGA-KIRC dataset. (B, C) Kaplan–Meier survival and ROC curves based on PRPCDGs risk signature. (D) Comparison of the risk score in high- and low-PRPCDGs-risk groups on gender, age, stage, grade, and therapy response in KIRC cohort and two external validation datasets (E-MTAB-1980 and TCGA-KIRP). (E) Uni- and multi-Cox regression analyses based on OS in KIRC cohorts. (F) Nomogram model of the 3-/5-/7-year survival probability of patients in KIRC cohort. (G) ROC curve in the presence of model’s predictive accuracy in KIRC dataset. (H) The calibration curve in the presence of 3-, 5-, and 7-year OS probability of the model in KIRC dataset. (I) DCA curve in the presence of 3-, 5-, and 7-year OS probability according to clinical models in KIRC dataset.