Research Paper Volume 15, Issue 22 pp 13010—13040

Identification of topoisomerase 2A as a novel bone metastasis-related gene in liver hepatocellular carcinoma

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Figure 2. The expression of TOP2A in LIHC. (A) The mRNA expression level of TOP2A of LIHC and normal tissues in TCGA database. (B) TOP2A mRNA expression of matched LIHC and normal tissues in TCGA database. (C) The mRNA expression level of TOP2A of LIHC and normal tissues in TCGA and GTEx database. (D) IHC of TOP2A protein expression in LIHC with different stage and normal liver tissues from tissue microarrays. (E) The mRNA expression level of TOP2A of LIHC, LIHC-BM and normal liver tissues in Tianjin Medical University Cancer Institute and Hospital. (F) IHC of TOP2A protein expression in three paired LIHC-BM lesions and counterpart primary LIHC tissues from Tianjin Medical University Cancer Institute and Hospital. Magnification: 200 ×, scale bars: 100 μm. ***P < 0.001.