Research Paper Volume 15, Issue 21 pp 12451—12475

Figure 11. SFTPC can inhibit the proliferation of LUAD in vivo. (A–D) Xenograft models and the tumor growth curves of LUAD tumor derived from A549 cells: overexpression of SFTPC significantly inhibited the proliferation of A549 cells in vivo (A, B), while knockdown of SFTPC significantly promoted their proliferation (C, D). (E–H) Xenograft models and the tumor growth curves of LUAD tumor derived from PC9 cells: overexpression of SFTPC significantly inhibited the proliferation of PC9 cells in vivo (E, F), while knockdown of SFTPC significantly promoted their proliferation (G, H). The volume of the tumor was measured every three days until the mice were euthanized, after which the tumor growth curves were drawn. (I–L) The weights of tumors were significantly decreased in the SFTPC overexpression groups (I–K), whereas they significantly increased in the SFTPC knockdown groups (J). After euthanizing the mice tumors were collected and weighed.