Figure 6. Core matrisome and matrisome-associated proteins are significantly altered in the ovary with advanced reproductive age. Quantification of core matrisome components (collagens, ECM glycoproteins, and proteoglycans) and matrisome-associated proteins (ECM regulators, ECM-affiliated proteins, and secreted factors) that are upregulated (A) and downregulated (B) in the ovary with advanced reproductive age.