Priority Research Paper Volume 15, Issue 20 pp 10821—10855

Proteomic quantification of native and ECM-enriched mouse ovaries reveals an age-dependent fibro-inflammatory signature

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Figure 6. Core matrisome and matrisome-associated proteins are significantly altered in the ovary with advanced reproductive age. Quantification of core matrisome components (collagens, ECM glycoproteins, and proteoglycans) and matrisome-associated proteins (ECM regulators, ECM-affiliated proteins, and secreted factors) that are upregulated (A) and downregulated (B) in the ovary with advanced reproductive age.