Research Paper Volume 15, Issue 21 pp 12369—12387

Figure 6. Immunological response and substantial heterogeneity occurred within BRCA and OV in accordance with CCL19 expression. (A) We studied several checkpoints expression level under high CCL19 expression and low expression in BRCA. (B) The difference of immune checkpoint between high expression group and low expression group of CCL19 in OV samples was also compared. (C) Tumor immune dysfunction and exclusion (TIDE) test was performed to check the immune infiltration in high expression group and low expression group of CCL19 in BRCA samples. (D) The difference of immune infiltration between high expression group and low expression group of CCL19 in OV was found with TIDE test. (E) We studied the correlation between CCL19 expression level and different immune cells in pan cancer. Red indicates a positive correlation between the expression of CCL19 and the activity of corresponding immune cells, while blue indicates a negative correlation.