Research Paper Volume 15, Issue 21 pp 12330—12368
A robust six-gene prognostic signature based on two prognostic subtypes constructed by chromatin regulators is correlated with immunological features and therapeutic response in lung adenocarcinoma
Figure 2. Identification of key differentially expressed chromatin regulators associated with survival. (A) Distribution of differentially expressed genes (DEGs) between lung adenocarcinoma (LUAD) and normal lung tissues. Totals of 2346 upregulated and 1966 downregulated DEGs were identified in LUAD tissue. (B) Identification of differentially expressed chromatin regulators (DECRs). Totals of 127 upregulated and 33 downregulated DECRs were identified in LUAD tissue. (C) Identification of key DECRs associated with overall survival (OS) rate of patients with LUAD. Univariate Cox regression analysis showed that 27 DECRs were associated with the OS of patients with LUAD. (D) Correlations between key prognostic DECRs in expression. Except three DECRs including MOCS1, CBX7 and CIT, the expressions of the other 24 DECRs showed strong positive correlations on the whole. (E) Heat map of key prognostic DECRs in expression. Except three DECRs including MOCS1, CBX7 and CBX6, the expression of the other 24 DECRs were upregulated in LUAD tissue.