Research Paper Volume 15, Issue 21 pp 12330—12368
A robust six-gene prognostic signature based on two prognostic subtypes constructed by chromatin regulators is correlated with immunological features and therapeutic response in lung adenocarcinoma
Figure 10. Correlations of six-gene signature with overall survival (OS) of patients in lung adenocarcinoma (LUAD). (A–H) Survival analysis based on eight independent LUAD datasets from the gene expression omnibus (GEO) database. Eight GEO-LUAD datasets were GSE3141, GSE72094, GSE26939, GSE30219, GSE31210, GSE37745, GSE50081 and GSE29016. For each dataset, LUAD patients in the low-risk subgroup had a higher OS rate than those in high-risk subgroup (p = 0.0045, < 0.0001, = 0.0038, = 0.021, = 0.016, = 0.0099, < 0.0001, = 0.00013, respectively), and the AUCs associated with 5-year survival were 0.67, 0.87, 0.65, 0.7, 0.67, 0.64, 0.7 and 0.78, respectively.