Research Paper Volume 15, Issue 21 pp 12209—12224
Effects of amyloid β (Aβ)42 and Gasdermin D on the progression of Alzheimer’s disease in vitro and in vivo through the regulation of astrocyte pyroptosis
Figure 1. Aβ42 promotes astrocyte proliferation. (A) CCK-8 assayed the cell proliferation ability of the control cells, 0.1 μmol Aβ42, or 1 μmol Aβ42-treated cells. (B) The effect of Aβ42 on astrocyte morphology was observed by scanning electron microscopy. (C) Real-time quantitative PCR was used to detect the relative expression of GFAP in the astrocytes treated with 1 μmol Aβ42. *p < 0.05, vs. control group (D) Detection of the GFAP expression in astrocytes by immunofluorescence.