Research Paper Volume 15, Issue 22 pp 12817—12851

Figure 6. CBX2 shaped diverse functional states and enhanced immunotherapy response. (A) The Pearson correlation between CBX2 and CD44 in TCGA-LICH dataset. (B, C) UMAP showing the cell clusters (B) and distribution of CBX2 (C) in GSE125449. (D, E) Distribution of CytoTRACE score between CBX2-positive and –negative malignant cells from GSE125449 (D) and GSE166635 (E). P-value was calculated using the two-sided Wilcoxon test. (F) Heatmap representation of the main functional states, immunotherapy response predictors, representative molecular and immune characteristics in CBX2^high tumors and CBX2^low tumors. (G, H) Kaplan-Meier plots of CBX2 combined with PDCD1 (G) and CD274 (H). P-value was computed with log-rank test. (I, J) Distribution of predicted TIDE score between CBX2-stratified (I) and CEP55-stratified (J) tumors. P-value was calculated using the two-sided Wilcoxon test.