Research Paper Volume 15, Issue 22 pp 12817—12851
Prognostic hub gene CBX2 drives a cancer stem cell-like phenotype in HCC revealed by multi-omics and multi-cohorts
Figure 1. Identification and validation of refined hubs in triple regulatory networks. (A–C) The overlapping differential expressed genes including lncRNAs (A), miRNAs (B) and mRNAs (C) identified by DESeq2 (FDR:0.01, log2FC:1) with TCGA-LIHC and GSE140845. (D) The Sankey plot indicates the triple regulatory network based on the strategies. The thickness of lines do not make sense. (E) Strategy-one hub of refined triple regulatory networks determined by a Cytoscape plug-in CytoHubba. (F) The base pairing diagram of binding sites for the strategy-one triple regulatory network predicted by miRanda. (G) The predicted cellular localization for 4 lncRNAs in the strategy-one hub using lncLocator. (H) The Pearson’s correlation between CBX2 and 4 lncRNAs in the strategy-one hub.