Figure 1. Overall working flowchart of bioinformatics analysis based on publicly available data in GEO public database. GEO, Gene Expression Omnibus; miRNA, microRNA; FC, fold change; RNA22, TargetScant, miRTarBase, microRNA-target interactions database; mRNA, messenger RNA. NC, normal control; MCI, Mild cognitive impairment; AD, Alzheimer’s disease.