Research Paper Volume 15, Issue 21 pp 12021—12067

Figure 8. Functional enrichment analysis for DEGs between High and Low expression of GPER1 expression in BRCA. (A) GO/KEGG pathway enrichment joint logFC for DEGs between High and -Low expression of GPER1 expression in BRCA presented as string graph. The left half of the figure shows the gene blocks, and the different colors of the blocks represent the corresponding logFC values. The right half of the graph shows the entry blocks, the size of the blocks represents the corresponding Counts, and the lines (strings) between the blocks on the left and right half of the graph represent the molecules contained in the entry, the presence of the lines means that the entry contains the corresponding molecules. (B) GO/KEGG joint logFC results presented as circle graph. The circle diagram can be divided into two parts: the inner circle and the outer circle. Each bar in the inner circle corresponds to an entry, and the height is the relative size of the p.adj. The higher the bar, the smaller the p.adj of the ID. The color of the corresponding filled column represents the Zscore value of the entry. (C) GO/KEGG pathway enrichment presented as bubble chart, (D) GSEA of the signaling pathways associated with DEGs of GPER1 expression in BRCA.