Research Paper Volume 15, Issue 24 pp 14651—14665
The peptide Acein promotes dopamine secretion through clec-126 to extend the lifespan of elderly C. elegans
Figure 4. Aging-associated phenotypic assay results in C. elegans overexpressing clec-126. (A) qPCR validation results of C. elegans overexpressing clec-126. (B) Lifespan experiments of C. elegans overexpressing clec-126. (C) Dopamine changes in C. elegans at 48 h. (D) Changes in dopamine levels in C. elegans with age. (E) Head swing in C. elegans overexpressing clec-126. (F) Body bending in C. elegans overexpressing clec-126. (G) Pharyngeal pumping in C. elegans overexpressing clec-126. (H) Survival curve of Day 8 C. elegans overexpressing clec-126 in a thermostressed environment at 35°C. (I) Head swing in C. elegans overexpressing clec-126 of different age groups. (J) Detection results of pharyngeal pumping frequency in C. elegans overexpressing clec-126 of different age groups. Compared with the vehicle group. nsp > 0.05, *p < 0.05, **p < 0.01, ***p < 0.001.