Research Paper Volume 15, Issue 24 pp 14651—14665
The peptide Acein promotes dopamine secretion through clec-126 to extend the lifespan of elderly C. elegans
Figure 2. Transcriptome sequencing revealed clec-126, a key gene for the anti-aging activity exerted by Acein. (A) Differential gene scatter diagram, a total of 98 genes were up-regulated (red) and 26 genes were down-regulated (green). (B) Selected differential gene heat map, the screening criteria were FC ≥ 2 or FC ≤ 0.5, P value ≤ 0.05, and the reproducibility of the parallel group was good. (C) qPCR validation results of 13 up-regulated genes. (D) qPCR validation results of 6 down-regulated genes. Compared with the vehicle group, *p < 0.05, **p < 0.01, ***p < 0.001.