Research Paper Volume 15, Issue 20 pp 11546—11553

Figure 1. ICA improves cognitive behavior in AD mice. (A–E) Morris water maze (n= 10). Compared to the Normal mice, AD mice exhibited longer escape latency, fewer platform crossings and shorter swimming distance. ICA could shorten the escape latency, increase the number of platform crossings and prolong the swimming distance. ^*P< 0.05 vs. Normal; ^#P< 0.05 vs. AD. (F, G) Iron content and JC-1 (n=10). In AD mice, the polymer/monomer ratio was downregulated, while the iron ion content was upregulated. ICA could lower the iron ion content in the brain, enhance the polymerization level and increase the polymer/monomer ratio. ^*P< 0.05 vs. Normal; ^#P< 0.05 vs. AD. (H, I) SOD and MDA (n=10). Compared to the Normal mice, the AD mice exhibited downregulated SOD and upregulated MDA. ICA could resist oxidative damage, inhibit the MDA level and elevate the SOD level. ^*P< 0.05 vs. Normal; ^#P< 0.05 vs. AD.