Research Paper Volume 15, Issue 20 pp 11532—11545

Indoxyl sulfate induced frailty in patients with end-stage renal disease by disrupting the PGC-1α–FNDC5 axis

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Figure 3. Area of collagen in skeletal muscle tissue in mice with 5/6 nephrectomy. (A) Masson’s trichrome staining of collagen fibers. (B) Area of collagen within the skeletal muscle was quantified for each group. **Sham + N/S vs. 5/6Nx + N/S, p < 0.05; ***5/6Nx + N/S vs. 5/6 Nx + RSV, p < 0.05.