Research Paper Volume 15, Issue 21 pp 11845—11859

Capsaicin alleviates doxorubicin-induced acute myocardial injury by regulating iron homeostasis and PI3K-Akt signaling pathway

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Figure 1. CAP alleviated DOX-induced myocardial injury. (A) Survival rate of mice injected with DOX or CAP+DOX (n = 20). (B) Echocardiographic images of CTL group, CAP group, DOX and DOX + CAP groups in at day 4 after injection. (C) Shortening fraction (left) and ejection fraction of mice at day 4 after injection (right) (n = 6). (D) Weight of mice (left) and anatomical appearance of mice heart (right) (n = 5). Data are shown as the mean ± SEM. Statistical significance was determined using two-tailed student’s t-test. *p < 0.05, **p < 0.01, ***p < 0.001.