Research Paper Volume 15, Issue 20 pp 11448—11470

Figure 9. Biological interaction network of PPIH and enrichment analysis of gene sets enriched in the target network of PPIH. (A) Protein – protein interaction (PPI) network of PPIH (top 50) (STRING database). (B) PPI network (top 20) and functional analysis of gene sets enriched in the target network of PPIH. Colors of the network edges indicate the bioinformatics methods applied: physical interactions, coexpression, predicted, colocalization, and pathway. Colors of the network nodes indicate the biological functions of enriched gene sets (GeneMANIA database). (C–E) The GO functional enrichment analysis predicted three main functions of 65 genes enriched in the target network of PPIH, including cellular component, biological process, and molecular function. (F) KEGG pathway analysis (bioinformatics database).