Research Paper Volume 15, Issue 20 pp 11448—11470
PPIH gene regulation system and its prognostic significance in hepatocellular carcinoma: a comprehensive analysis
Figure 7. Genetic alterations and upregulation of Ppih were associated with poor prognosis in HCC patients. (A) The PPIH alteration frequency in HCC is presented as a bar diagram. (B, C) Genetic alterations in PPIH were associated with worse DFS (B) and OS (C) of HCC patients (cBioPortal database). (D–G) Graphs generated from the DriverDBV3 database show the prognostic values of PPIH in HCC patients. (H) Kaplan-Meier survival analysis of the prognostic value of PPIH in the ICGC validation set. (I–K) The relationship between Ppih expression and OS in HCC patients with or without mutated TP53 based on TCGA database. Abbreviations: OS: overall survival; PFI: progression free interval; DFI: disease free interval; and DSS: disease-specific survival.