Research Paper Volume 15, Issue 20 pp 11331—11368

Figure 8. Differential expression and functional similarity analysis. (A) Volcano plot of DEGs between high and low-risk groups in TCGA-PAAD, mapping 8016 upregulated genes (red dots) and 5254 downregulated genes (blue dots). No significantly changed genes are marked as gray dots. (B) The heatmap to show high and low-risk groups and 7 key gene expressions. (C, D) Boxplots to show the expression difference of ABCB1, CAP1, EGFR, ITGB1, MAPK1, PPARG, and SNCA between high and low-risk groups in TCGA-PAAD dataset (C) and Dataset PAAD (D). (E) Raincloud plots to show the functional similarity analysis of 5 hub genes; X-axis represents a similarity score, and the larger the value, the higher the functional similarity with other genes. (F) Chromosomal mapping of 5 Hub genes. Ns represents P-value ≥ 0.05, with no statistically significant difference; * represents P-value < 0.05, with a statistically significant difference; ** represents P-value < 0.01; *** represents P-value < 0.001.